CD276 and neoplasm: The unpredictable off-tumor toxicity associated with GD2 CAR-T cells, combined with our work demonstrating impressive in vitro and in vivo anti-NBL efficacy of a B7H3 CAR, led us to develop SynNotch-gated GD2 and B7H3 CAR-T cells, which have improved specificity and avoid neurotoxicity while retaining the ability to control tumor growth and cure metastatic NBL.