On day 48, compared to the control mice, mice implanted with HOXB4-depleted SiHa cells showed larger tumor volumes, with a 17.1-fold increase in tumor size and a 5.8-fold increase in tumor weight; these mice also had shortened tumor-free survival (Fig. 2e–g and Supplementary Fig. 1f). Here, HOXB4 is linked to neoplasm.