E2F4 and cancer: Taken together, these findings suggest a model wherein NF-Y, in collaboration with E2F4 and/or MYBL2 complex, binds to and activates transcription of E2F/NF-Y-dependent switch genes accelerating the late phase of the cell cycle by promoting angiogenesis with a consequent increase of cancer progression, together with a rewiring of some metabolic pathways, hallmarks of the malignant transformation.