[Stem-like cells determine tumor aggressiveness by sustaining tumor growth and causing relapse and metastasis by their resistance to conventional cancer therapies26.] In particular, the role of FOSL1 was explored and found to be a repressor of a core of four master neurodevelopmental transcription factors whose induction is sufficient to reprogram fully differentiated glioblastoma cells into stem-like cells27. This evidence concerns the gene FOSL1 and neoplasm.