Of 10 cancer-specific point mutations in the (alt-)RPL36 coding sequence (CDS) in the COSMIC database (cancer.sanger.ac.uk)41, 2 alter the amino acid sequence of RPL36 but are synonymous in the alt-RPL36 reading frame; 4 affect both the RPL36 and alt-RPL36 amino acid sequences; and, remarkably, 4 are synonymous with respect to RPL36 but create nonsynonymous mutations in the alt-RPL36 reading frame. This evidence concerns the gene RPL36 and cancer.