Interestingly, inhibition of SUMOylation promotes the translocation of CD115 from the cytoplasm to the cell membrane.108 This has potential clinical implications for treating CD115-expressing cancers because the translocation of CD115 to the cell surface clearly facilitates tumor cell recognition by innate immune cells and increases tumor cell susceptibility to NK cell-mediated cytolysis. This evidence concerns the gene CSF1R and neoplasm.