Loss of FBW7 expression results in increased Snail protein abundance, thereby causing epithelial-mesenchymal transition and tumor metastasis.27 More strikingly, a very recent study highlighted that inactivation of FBW7 was associated with altered immune microenvironment, decreased tumor-intrinsic expression of the double-stranded RNA (dsRNA) sensors melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene I (RIG-I), and diminished induction of type I IFN and MHC-I expression. The gene discussed is IFIH1; the disease is neoplasm.