USP22 and triple-negative breast carcinoma: For example, a very recent study showed a high level of GATA-binding protein 3 antisense RNA 1 (GATA3-AS1) in triple negative breast cancer, GATA3-AS1 sequesters miR-676-5p and increases the expression of CSN5.54 Moreover, ubiquitin-specific peptidase 9, X-linked (USP9X),55 ubiquitin-specific peptidase 22 (USP22)56 and ubiquitin C-terminal hydrolase L1 (UCHL1)57 have been demonstrated to deubiquitinate and stabilize the PD-L1 protein.