Analysis of the tumor-infiltrating CD4+ T-cell population showed that CD4+CD103+ TRMs expressed IFNγ in higher frequencies than CD69− T cells, and TNFα in greater percentages than CD69− T cells and CD103− TRMs, but there were no significant differences between the CD4+CD103+ TRMs and the other T-cell subsets in the expression of IL-2 (online supplemental figure 5A-C). Here, CD4 is linked to neoplasm.