CD8A and lung cancer: Consistent with this, in lung cancer CD103+CD45RO+CD8+ T cells are the main source of IFNγ in tumor-infiltrating lymphocytes, and CD8+CD103+ T cells can augment cytotoxic CD8+ T-cell cancer recognition and enhance antitumor cytotoxicity.28 31 However, in the current study, we also noted that CD8+CD103+ TRMs in cSCC exhibited increased production of the immunosuppressive cytokine IL-10, the ectonucleotidase CD39 (a rate limiting enzyme for the generation of immunosuppressive adenosine) and upregulation of the exhaustion marker PD-1.