ITGAE and hereditary clear cell renal cell carcinoma: To investigate the association between CD103 expression and survival in other cancer types, TCGA data were analyzed using TIMER2.0,17 demonstrating that high (greater than median) expression of ITGAE (encoding CD103) was associated with reduced survival in primary cutaneous melanoma, breast carcinoma, renal cell carcinoma, kidney chromophobe cancer and lower grade glioma, figure 6D, whereas two cancer types showed the opposite association (high ITGAE expression was associated with increased survival in cervical/endocervical cancer and pancreatic adenocarcinoma).