EGFR and head and neck squamous cell carcinoma: Proteomic analyses have revealed that EV-derived proteins of tumour necrosis factor (TNF) receptor associated protein 1(TRAP1), epidermal growth factor receptor (EGFR), heat shock protein 90 (HSP-90), desmonglein-2 (Dsg-2) and matrix metalloprotein-2/9/13 (MMP) mRNA were significantly overexpressed in HNSCC [39–42].