Moreover, TDE rich in miRNA-196a and miRNA-21 mediated cisplatin resistance of oral squamous cell carcinoma by targeting PTEN/PDCD4 (programmed cell death 4) and (cyclin dependent kinase inhibitor 1B)CDKN1B/ING5(inhibitor of growth5), respectively [71, 152, 153]. This evidence concerns the gene CDKN1B and oral cavity squamous cell carcinoma.