IRF4 and colorectal carcinoma: In an endeavor to achieve better sensitivity, we developed a multi-target qPCR assay detecting an additional DMR in IRF4 as well as detecting an additional DMR in IKZF1. The resulting multi-target qPCR assay was evaluated in a population comprising the spectrum of pathologies typically encountered when screening for CRC and which was more diverse than the cohort used in our initial discovery [10].