CD8A and Autoimmunity: Altogether, our analysis of immune processes revealed by the blood multi-omics signature associated with IA progression lends support to a model in which ROS stimulates increased activity of antigen-presenting cells and decreased activity of Tregs within an environment that favors immune-cell patrol, activation of autoimmunity, and migration of cytotoxic-CD8+ T and NK cells towards to pancreatic islets, where they coordinate the degradation of β cells.