CDH1 and neoplasm: Notably, we detected that some cells in tumors generated by Pdgfrβ KO p18−/−;Brca1MGKO cells expressed high levels of E-cad, whereas E-cad-positive cells in tumors generated by Pdgfrβ WT p18−/−;Brca1MGKO tumor cells were rarely observed (Fig. 4h).