YCHD was reported integrating multiple signaling pathways on cancers, immune system, infectious diseases, etc. Furthermore, YCHD probably exerted the therapeutic effects on cholangiocarcinoma by regulating signaling pathways, which included hepatitis B, the MAPK signaling pathway, the PI3K-Akt signaling pathway, and MicroRNAs in cancer. This evidence concerns the gene AKT1 and cholangiocarcinoma.