AKT1 and cholangiocarcinoma: Except for regulation of quercetin on the PI3K-AKT and MAPK pathways described above, quercetin has the ability of inhibiting cell migration and angiogenesis mediated by downregulating VEGFA levels in glioblastoma cells [56], whereas no study has focused on the relationship of quercetin and VEGFA in treating cholangiocarcinoma.