MPEG1 and experimental autoimmune encephalomyelitis: Likewise, microglia activation also begins early in disease development [38] as RNAseq demonstrated that Mpeg1, a macrophage marker expressed also in microglia, was DE in 1-month Mcoln1−/− mice, as was Cxcl10, whose levels are also altered in models of experimental autoimmune encephalomyelitis [40].