Glomerulosclerosis either of the nodular or diffuse types, interstitial fibrosis with infiltration by mononuclear inflammatory cells, hyalinization of the renal arterioles, linear deposits of Igs (Immunoglobulins) in glomerular basement membrane on immunofluorescence studies and diffuse thickening of glomerular basement membrane on electron microscopy examination. Here, CUBN is linked to glomerulosclerosis.