CDKN2B-AS1 and type 2 diabetes mellitus: Although the mechanism of how ANRIL regulates glucose metabolism and insulin secretion is unknown, the circulating expression of ANRIL was higher in T2D patients, patients with myocardial infarction (MI) only, and much higher in T2D patients with MI, thus indicating the role of ANRIL in CVD progression of T2D patients [92].