Brachyury over-expression promoted up-regulation of TGF-β1 through activation of the TGFB1 promoter, while inhibition of TGF-β1 signaling decreased the expression of this TF, eventually resulting in the establishment of a positive feedback loop between Brachyury and aTGF-β1 in mesenchymal-like tumor cells [46]. Here, TGFB1 is linked to neoplasm.