Tumor-derived TGF-β acting on stromal fibroblasts generates cancer-associated fibroblasts (CAFs), remodels the tumor stroma and eventually induces expression of mitogenic and survival signals towards the carcinoma cells, while TGF-β acting on endothelial cells and pericytes regulates (neo)angiogenesis [3]. Here, TGFB1 is linked to neoplasm.