The selective effect of aTGF-β on invasion and metastasis was subsequently confirmed by the reverse approach, antisense-mediated inhibition of TGF-β1 in the tumor cells, indicating that the induction and/or activation of TGF-β in hosts with already established TGF-β-responsive cancers can rapidly accelerate metastatic progression [28]. The gene discussed is TGFB1; the disease is cancer.