These cells increasingly acquired two autocrine signaling loops, mediated by TGF-β and stromal cell-derived factor 1 (SDF-1) cytokines, which both act in autostimulatory and cross-communicating fashions to initiate and maintain the differentiation of fibroblasts into myofibroblasts and the concurrent tumor-promoting phenotype [83]. Here, TGFB1 is linked to neoplasm.