TGF-β/Smad signaling was identified as a major driver of ZNF217-induced EMT and a TGF-β autocrine loop maintained by ZNF217-mediated up-regulation of TGFB2 or TGFB3 sustained activation of the TGF-β pathway in ZNF217-overexpressing BC cells [45]. This evidence concerns the gene TGFB1 and breast cancer.