Up-regulation and activation of the receptor tyrosine kinase, Axl, in EMT-transformed hepatoma cells caused phosphorylation of Smad3 in its linker region, resulting in the induction of PAI-1, matrix metalloproteinase-9 (MMP-9), and Snail as well as TGF-β1 secretion in mesenchymal HCC cells. The gene discussed is AXL; the disease is hepatocellular carcinoma.