RIGI and viral infectious disease: Because NSs of all three orthohantaviruses appeared to be efficient antagonists of RIG-I-induced IFN-I activation, we investigated the role of NSs during viral infection by taking advantage of viral strains expressing either a full-length NSs (PUUV Sotkamo wild-type, TULV Lodz) or a truncated NSs (PUUVΔNSs, TULV Moravia).