CXCR1 and idiopathic pulmonary arterial hypertension: More importantly, the ROC curve analysis of the Lasso regression model showed that the AUC values were all above 0.9, indicating the outstanding potential of the 5 hub DEGs, namely, CXCR1, CCL5, ADORA3, CCR1, and SAA1, as biomarkers for distinguishing IPAH patients, which has significant clinical feasibility in auxiliary diagnosis and disease classification.