It has been reported that over-expression of PKM1/2 isoforms promotes tumorigenesis or induces poor prognoses of patients in multiple cancers [19,22,23,24,25,26,27,28,29,30,31,32,33] whereas PKM1 expression in place of PKM2 inhibits tumor cell proliferation [34,35]. The gene discussed is PKM; the disease is neoplasm.