Therefore, we investigated the expression of SPAAR with single-cell RNA sequencing (scRNAseq) data mining of human cardiac cell populations, the expression of the LINC00961 locus in a mouse endothelial-like cell line, and the effects of CRISPR/Cas9 LINC00961 locus deletion on murine growth and development, basal cardiac function, risk area following acute cardiac ischaemia, and physiological function following 7 days of chronic cardiac ischaemia in a surgical model of MI. The gene discussed is SPAAR; the disease is myocardial infarction.