The extracellular release of high mobility group box 1 (HMGB1) and adenosine triphosphate (ATP) attracts and activates antigen-presenting cells (APCs), and the translocation of calreticulin (CRT) on the surface of dying cancer cells serves as an “eat-me” signal to phagocytes [25,26,27]. Here, HMGB1 is linked to cancer.