Little is known about TMEM154 function; apart from the transmembrane location, GWAS studies have identified TMEM154 as a candidate for asthma severity [48] and for type-2 diabetes in a meta-analysis, which combined GWAS data from multiple human ethnic groups, including European, East Asian, South Asian, and Mexican/Mexican American [49,50,51,52], both studies relating TMEM154 to inflammatory processes. Here, TMEM154 is linked to asthma.