On the other hand, two distinct mechanisms have been put forward depending on DLBCL type: The ABC subtype seems to use a pathway linking JMJD3–IRF4–NF–kB to induce cell survival, while for the GCB subtype, survival is mediated by the Bcl-2 survival gene, which is sensitive to JMJD3 demethylase activity [78]. Here, IRF4 is linked to diffuse large B-cell lymphoma.