This comment also applies to JMJD3’s enrichment on four candidate genes (O—methylguanine-DNA methyltransferase (MGMT), transformer 2 alpha homolog (TRA2A), 2 small nuclear RNA auxiliary factor 1 (U2AF1), and ribosomal protein S6 kinase A2 (RPS6KA2)), identified as signature genes in PC [59]. Here, RPS6KA2 is linked to pachyonychia congenita.