CST5 and neoplasm: Although the mechanism remains unclear, JMJD3’s presence limits the expression of key participants implied in EMT (SNAI1, Zinc finger E-box-binding homeobox 1 (ZEB1)) and facilitates chromatin access to the genes involved in cell adhesion and the 1,25(OH)2D3 target genes (CYP24A, CDHA1/E-cadherin, and CST5/cystatin D), all of which have a role in restraining tumor progression [82,83].