KDM6B and central nervous system cancer: These results were later confirmed after JMJD3 inhibition by Clustered Regularly Interspaced Short Palindromic Repeats Interference (CRISPRi), which still resulted in a decrease in glioma cell proliferation, migration, and invasion, making JMJD3 an oncogene involved in the epithelial–mesenchymal transition (EMT).