ESR1 and neoplasm: Another study showed the impact of H3K27me3 on the regulation of the Retinoic acid receptor β2 (RARβ2), estrogen receptor (Erα), progesterone receptor (PGR), and Repulsive Guidance Molecule A (RGMA) genes and also correlated H3K27me3 with the level of tumor aggressivity [57].