Moreover, it seems that the association of GSK-J4 with a natural cAMP raising compound (forskolin) potentiates the anti-proliferative effects of GSK-J4 via PKA in some AML cells (U937 cells), leading to B-cell lymphoma 2 protein (BCL2) downregulation and caspase 3 activation [74]. The gene discussed is BCL2; the disease is acute myeloid leukemia.