P2RY12 and ischemia: For example, in a sub-analysis of the randomized GRAVITAS (Gauging Responsiveness with a Verify Now P2Y12 assay: Impact on Thrombosis and Safety) study [24], HPR (defined as >208 P2Y12 reaction units when examined with a point-of-care Verify Now® assay at 12 to 24 h after PCI) was connected with a higher risk of adverse ischemia at 60 days and at 6 months (at 60 days: hazard ratio [HR]: 0.18; 95% confidence interval [CI]: 0.04–0.79; p = 0.02; at 6 months: HR: 0.43; 95% CI: 0.23–0.82; p = 0.01).