Furthermore, the levels of other inflammation-associated receptors (e.g., TLR2, TLR4, and RAGE) were elevated in diabetic nephropathy kidney tissue, together with DAMPs, such as AGEs, HMGB1, HSP70, and S100 calgranulins (e.g., S100A8 and S100A9), triggering their activation. This evidence concerns the gene TLR4 and diabetic kidney disease.