IL-10-induced TNF-α inhibition in these cells could be attributable to the destabilization of TNF-α mRNA expression via the suppression of p38 MAPK activation and the inhibition of NF-κB and RNA-binding Hu-antigen receptor (HuR) expression, all of which induce an inflammatory reaction and tissue injury during the course of diabetes and diabetic nephropathy. This evidence concerns the gene TNF and diabetic kidney disease.