Both plasma and urine levels of soluble Klotho were lower in intrinsic AKI patients compared with prerenal AKI patients, together with an increase in levels of proinflammatory ligands (i.e., S100A8/A9 calgranulins) of Toll-like receptor 4 (TLR4) [24]. Here, IGKV1D-22 is linked to acute kidney injury.