Also, the Werner (WRN) gene, which is a human RecQ DNA helicase with both a 3′ to 5′ helicase activity and a 3′ to 5′ exonuclease activity [129], has been identified as a tumor suppressor gene where any germline mutation in its sequence can cause Werner’s syndrome (WS) with an increased risk of tumor development [130]. Here, WRN is linked to neoplasm.