HSC harvested from HRP-2+/+, HRP-2+/− and HRP-2−/− mice were transduced with lentiviral vectors encoding one of the most common MLL-fusion proteins (MLL-ENL) or a control fusion inducing ALL (E2A-HLF) and their transformation potentials were compared in serial plating assays (Figure 5A). The gene discussed is HDGFL2; the disease is acute lymphoblastic leukemia.