HULC and liver cancer: Among 4238 differentially expressed (DE) evolutionary conserved non-coding RNAs, there were 94 known, putatively conserved DE lncRNAs identified, including MALAT1, HOXA transcript at the distal tip (HOTTIP), HOX transcript antisense RNA (HOTAIR) and highly up-regulated in liver cancer lncRNA (HULC) (Figure 2E–H).