Downregulation of miR-483–5p and miR-486–5p was observed in the cumulus granulosa cells surrounding metaphase II oocytes of women with PCOS and the former was shown to be involved in the proliferation of granulosa cells of PCOS through induction of the PI3K/Akt pathway [49]. The gene discussed is AKT1; the disease is polycystic ovary syndrome.