TNF and endometritis: It was also shown that miR-218 was one of the differentially expressed miRNAs and involved in the pathogenesis of bovine endometritis and bovine endometrial cells are reported to use the EVs to encapsulate and release the miR-218 into the uterine environment, which acts as an inhibitor of immune factors like the IL-6, IL-1b, and TNFα and inflammatory genes [95].