BRAF and neoplasm: In the ACT-3 trial, patients who are ctDNA-positive after completion of 3–6 months of adjuvant FOLFOX or CAPOX are randomised to surveillance (control) or several molecularly-stratified “second-line” adjuvant therapies (experimental) including FOLFIRI (for microsatellite stable and BRAF wild-type tumours), encorafenib/binimetinib/cetuximab (for BRAFV600E mutant tumours), and Nivolumab (for microsatellite unstable tumours).