ENTPD1 and neoplasm: Thus, Zhang et al. [60] demonstrated that EVs released from rodent B lymphocytes and not those from NIH-3T3, which are a line of fibroblast-like cells, contain high levels of CD39 and CD73 that hydrolyze ATP released from chemotherapy-treated tumor cells into ADO, in turn inhibiting CTLs and therefore attenuating the chemotherapeutic efficacy.