CCND1 and cancer: In cancer cells, La-dependent translation of target mRNAs causes increased expression of cell cycle regulator cyclin D1 [9], p53-negative regulator mouse double minute 2 (Mdm2) [12], extracellular matrix protein laminin B1 [13], and antiapoptotic factors B-cell lymphoma 2 (Bcl2) and X-linked inhibitor of apoptosis protein (XIAP) [14,15].