Recently, we identified an RNA chaperone domain (RCD) in the carboxyterminal part of RBP La that is able to unwind RNA stem-loop structures located within the 5′-untranslated region (5′UTR) of cyclin D1 and Bcl2 mRNA, hindering efficient translation in vitro and in cell-based assays [14,16], supporting a model that suggests that the RNA chaperone activity of La contributes to overexpression of oncogenic factors in cancer cells. The gene discussed is SSB; the disease is cancer.