APOC3 and type 1 diabetes mellitus: When islets from neonatal rats were incubated with the islet cytotoxic cytokines, IL-1β and interferon-γ, to mimic the intraislet inflammatory milieu seen in T1D, the addition of apoCIII to the incubation medium provided protection against apoptosis by degradation of the inhibitor of κΒ (IκΒ) and stimulation of the phosphorylation of survival serine-threonine kinase Akt [67].