In the diabetes-prone Biobreeding (DPBB) rat, which develops human-like T1D within a narrow time window of around 60 days [91,92,93], the onset of diabetes was prolonged when apoCIII was lowered during 28 days of the prediabetic phase (from 12 to 40 days of age), when the rats were not insulin deficient and had normal blood glucose levels [93]. Here, INS is linked to type 1 diabetes mellitus.