HERC1 and chronic myelogenous leukemia, BCR-ABL1 positive: Our findings revealed that HERC1 gene expression was severely down-regulated both in acute and in chronic myelogenous leukemia while it is peculiarly modulated in the myeloproliferative neoplasms, suggesting that in myeloid malignancies HERC1 display either tumor-suppressing and -promoting properties depending on the context.