HERC1 and chronic myelogenous leukemia, BCR-ABL1 positive: Hence, it is conceivable to hypothesize that: (a) in AML, PMF and CML, HERC1 might act as an oncosuppressor [36] and (b) though genotypically different all these myeloid disorders share a common HERC1 transcriptional repressor mechanism that in CML it is positively regulated by BCR-ABL1.