IDH2 and acute myeloid leukemia: By comparing the HERC1 transcript among the different categories we did not observe any major difference (Figure 2B) besides the IDH2 mutated specimens, in which the HERC1 gene expression was significantly higher when compared to all the other AML subgroups (ANOVA, p = 0.03), displaying a median level (1.9) similar to that of the healthy donors (p = 0.27).