A good example is quercetin that, in cellular models of CLL, and in association with the BH3-mimetic ABT-737, synergistically enhanced apoptosis by directly targeting PI3K and CK2 kinases, being the latter a positive modulator of the PI3K/AKT pathway since it inactivates PTEN phosphatase [19,20]. The gene discussed is AKT1; the disease is B-cell chronic lymphocytic leukemia.