OPA1 and Leber hereditary optic neuropathy: Other iPSC lines were generated from fibroblasts obtained from patients with an optic atrophy “plus” phenotype: one carrying the mutation c.1861C>T; p.Gln621Ter in OPA1 [96] and the other one harboring the mutation c.1635C>A; p.Ser545Arg in OPA1, both of them in heterozygosis [97].