In other models of kidney disease, including autoimmune nephritis, toxic injury, ischemia reperfusion injury (IRI), ureteral obstruction, and podocyte injury, Nrf2 KO organisms also displayed an increase in disease severity, suggesting that NRF2 plays a nephroprotective role through a common pathway [39,40,41,42,43,44,45,46,47,48,49,50]. Here, NFE2L2 is linked to kidney disorder.