Vigneswaran et al. also showed that YAP/TAZ transcription cofactors regulate the expression of SOX2 (SRY-box transcription factor 2), C-MYC, and EGFR to create a feedforward loop to maintain the proliferation and survival of EGFR-amplified/mutant human GBM cells [87]. Here, SOX2 is linked to glioblastoma.