RUNX2 and bone inflammation disease: In a murine eosinophilic CRS model induced by the administration of ovalbumin and staphylococcal enterotoxin B, histological and radiographic findings of osteitis were identified, thereby demonstrating the positive correlation among bone thickness, Runt-related transcription factor 2 (RUNX2)-immunoreactive osteoblasts, and IL-13 expression [112].