In diabetic nephropathy, proximal tubule-specific overexpression of CAT inhibited renal ROS production and tubulointerstitial fibrosis and attenuated angiotensinogen, p53, and proapoptotic Bcl-2 associated X-protein (BAX) gene expression in STZ-treated diabetic mice and db/db mice [57,58]. The gene discussed is CAT; the disease is diabetic kidney disease.