There is a number of E-selectin ligands that are expressed on migrating cancer cells (Table 1) including E-selectin ligand (ESL-1) [37], L-selectin (CD62L) [38], P-selectin glycoprotein ligand-1 (PSGL-1, CD162) [15,18,22,39,40,41,42], CD43 [43,44], homing cell adhesion molecule 1 (HCAM1; CD44) [35,42,45,46], death receptor 3 (DR-3) [31,32] and cutaneous lymphocyte-associated antigen (CLA) [45,46]. This evidence concerns the gene SELE and cancer.