AMD risk alleles within the SLC16A8 gene could alter transepithelial transport of lactate through the RPE since it involves two distinct transporters MCT1 (SLC16A1) on the apical side, toward photoreceptors, and MCT3 (SLC16A8) on the basal side, toward the choroid [16]. This evidence concerns the gene SLC16A8 and age-related macular degeneration.