FGF-21 levels were significantly (p = 0.014) increased in patients with AS compared to control subjects (Figure 4A), but we did not find any statistically significant differences between controls and patient groups with different degrees of AS (Figure 4B), although the correlation analysis showed a weak positive relationship (p = 0.02) of FGF-21 levels regarding AS severity degree (Figure 4C). Here, FGF21 is linked to aortic valve stenosis.