In all three patient groups, FGF-2 correlated with VEGF-A (mild p = 0.01, moderate p = 0.0003, and severe degrees of AS p = 0.003) (Figure 7), whereas in patients with a severe degree of AS, GDF-15 correlated with Ang-2 (p = 0.001) (Figure 8). The gene discussed is GDF15; the disease is aortic stenosis.