SBSN and esophageal squamous cell carcinoma: SBSN-2 in ESCC cell lines increased the activity of WNT/β-catenin signalling pathway, which resulted in TCF/LEF transcriptional activity, nuclear translocation and reduced phosphorylation of WNT/β-catenin, and increased transcript levels of WNT/ β-catenin signalling-regulated genes such as AXIN2, MYC, CCND1, FRA1, MMP7 and JUN. The effect of SBSN on WNT signalling was mediated by phosphorylation of GSK3 β.