On the basis of transcriptomics and DNA methylation patterns, ependymoma has also been delineated into multiple subgroups, of which posterior fossa A ependymoma (EPN_PFA) and C11orf95 fusion-positive ependymoma (formerly EPN_RELA, and recently renamed due to the identification of other fusion partners for C11orf95) predominate in children [11,12]. Here, ZFTA is linked to ependymoma.