Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents (anti-VEGF therapy) is the most common molecular-targeted therapy in ophthalmology and is commonly used for various retinal diseases, such as age-related macular degeneration, diabetic retinopathy, and retinal vein occlusion [29,30,31]. This evidence concerns the gene VEGFA and diabetic retinopathy.