In our earlier pilot study using similar doses of tocotrienol-rich vitamin E, there were no significant changes in the serum biomarkers AGE, RAGE, Nε-CML, Cystatin C, TNFR-1, MDA, and thromboxane, although significant improvement in renal function was detected. This evidence concerns the gene TNFRSF1A and chronic myelogenous leukemia, BCR-ABL1 positive.