First, Ixolaris has been shown to inhibit the growth of U87-MG cells in nude mice without visible bleeding [135], and the inhibitory effect of Ixolaris on tumor growth was accompanied by downregulation of vascular endothelial growth factor (VEGF) and a decrease in tumor vasculature in a human glioblastoma model [135,136]. This evidence concerns the gene VEGFA and glioblastoma.