In particular, it has been reported that many of the potential benefits of regulating SGLT2 in both diabetic and non-diabetic patients with HF have been attributed to the slowing of the atherothrombotic processes which accompany type 2 diabetes mellitus (T2DM), and the improvement in the cardio-renal consequences of T2DM, which can lead to myocardium decay. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.