Of note, htgCB1 mice displayed down-regulation of IDE and its proteolytic activity, but unaltered levels of phosphorylated carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), in parallel with hepatic insulin resistance, lower insulin clearance and moderate hyperinsulinemia [180]. The gene discussed is CEACAM1; the disease is Hyperinsulinemia.