Interestingly, EB has an insulin-mimetic action, reducing hyperglycemia, enhancing glucose uptake in peripheral tissues [218], restoring glucose-stimulated insulin secretion in pancreatic β-cells [219], and improving hepatic insulin signaling and β-cell survival [220], suggesting that EB-mediated IDE inhibition may be involved in the mechanism of action of this compound. The gene discussed is INS; the disease is Hyperglycemia.