Interestingly, Lu and colleagues proved that curcumin administration could ameliorate GDM by increasing AMP-activated protein kinase (AMPK) activation in the livers of GDM mice and ameliorating oxidative stress by increasing Catalase (CAT), thiobarbituric acid reactive substance (TBARS), glutathione (GSH) and superoxide dismutase (SOD) levels [105]. The gene discussed is SOD1; the disease is gestational diabetes.